Reference of 372118-67-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.372118-67-7, name is Pyrimidin-2-ylmethanamine hydrochloride, molecular formula is C5H8ClN3, molecular weight is 145.5901, as common compound, the synthetic route is as follows.
A mixture of 8-bromo-5-[5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5- (trifluoromethyl)-3-isoxazolyl]isoquinoline (180 mg, 0.35 mmol), 2-aminomethylpyrimidine hydrochloride (154 mg, 1.41 mmol), [l,r-bis(diphenylphosphino)ferrocene]- dichloropalladium(II) (29 mg, 0.04 mmol) and triethylamine (0.49 mL, 3.5 mmol) in toluene (10 mL) was stirred at 80 C under one atmosphere of carbon monoxide for 6 hr. The reaction mixture was then filtered through a short pad of Celite, rinsed with ethyl acetate, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography using ethyl acetate/methanol as eluent to afford the title compound, a compound of this disclosure, as a yellow solid (88 mg, 45% yield, 0.16 mmol). 1H NMR (DMSO-d6): 9.83 (s, 1H), 9.46 (t, 1H), 8.86 (d, 2H), 8.71 (s, 2H), 8.17 (d, 1H), 7.92 (d, 1H), 7.90 (s, 1H), 7.88 (s, 1H), 7.47 (t, 1H), 4.78 (d, 2H), 4.62 (d, 1H), 4.58 (d, 1H).
Statistics shows that 372118-67-7 is playing an increasingly important role. we look forward to future research findings about Pyrimidin-2-ylmethanamine hydrochloride.
Reference:
Patent; FMC CORPORATION; XU, Ming; LAHM, George Philip; (109 pag.)WO2020/55955; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
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