New downstream synthetic route of 3764-01-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3764-01-0, 2,4,6-Trichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference of 3764-01-0, Adding some certain compound to certain chemical reactions, such as: 3764-01-0, name is 2,4,6-Trichloropyrimidine,molecular formula is C4HCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3764-01-0.

To an ice-cold solution containing 2,4,6-t?chloropy?midine (50 g, 0.27 mol) in MeOH (500 mL) and NaHCO3 (114 g, 1.35 mol) add slowly and dropwise a methanolic solution (10 mL) of morphohne (23.7 g, 0.27 mol) Allow the mixture to warm to 250C and stir overnight. Concentrate under vacuum, extract with EtOAc (500 mL), wash with water and dry with MgSO4 Filter and evaporate under vacuum to afford a white solid. Purify the crude by flash column chromatography to afford the title product as white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3764-01-0, 2,4,6-Trichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROGEN CORPORATION; WO2006/65872; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia