Synthetic Route of 37972-24-0, Adding some certain compound to certain chemical reactions, such as: 37972-24-0, name is 2-Ethynylpyrimidine,molecular formula is C6H4N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37972-24-0.
To a solution of 229(100mg, 0347mmo1) and 4(723mg, 0.694mmo1) in 2OmL of Et3N was added Pd(PPh3)2C12 (12.18mg, 0Oi7mmoi) and CuT (661mg, 0O35minoi). The mixture wasprotected with N2 atmosphere, then was heated at 70¡ãC for 24 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 117(18mg, yield: 1962percent).LCNIS: rn/z 265 (M*H)t?H NMR (400 MHz, CDCI3): 5 8.77 (d, J 4.8 Hz, 2H), 7.87 (d, J= 2.4 Hz, 1H), 771-768 (m, 2H, 7.28-7.26 (m, IH), 7.19-7.15 (m, 2H), 679 (d, J= 2.8 Hz, IH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 37972-24-0, 2-Ethynylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia