As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3934-20-1, name is 2,4-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 3934-20-1
56.8g (381mmol) 2,4-dichloropyrimidine was dissolved in 500ml of ethylene glycol dimethyl ether (0 leg), 50.1g (381mmol) of anhydrous AlCl3 was added under N2 protection conditions, stirred for 5min, added 50g (381mmol) of intermediate 2, heated to 80 CStir for 3 h. After the reaction was completed, it was cooled to room temperature, and the above mixed solution was added dropwise to 500 mL of vigorously stirred water, stirred at room temperature for 3 hours, and suction filtered to give a dark red solid. The filter cake was washed with water and methanol until the filter cake turned white and dried. 65. 1g of white solid, yield 70.1%,
The chemical industry reduces the impact on the environment during synthesis 3934-20-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Zhao Bingbing; Xu Shan; Xiao Zhen; Hu Xiaohan; Zhou Zhihui; He Jie; Lai Luogen; Yang Qi; Tian Fajuan; (31 pag.)CN109280048; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia