A common compound: 3934-20-1, name is 2,4-Dichloropyrimidine,molecular formula is C4H2Cl2N2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 3934-20-1
To a solution of 2, 4-dichloro-pyrimidine (15-0 g) in THF (150 mL) was added 50% aqueous Me2NH (22.7 g). The mixture was stirred at ambient temperature for 2 hr and poured into saturated aqueous NaHC03. The aqueous layer was extracted with CHC13 (three times). The combined organic layer was dried over MgS04, filtrated, concentrated under reduced pressure, and purified by flash chromatography (NH-silica, 20% EtOAc in hexane) to give (2-chloro-pyrimidin-4-yl)-dimethyl-amine (8.66 g) and (4-chloro- pyrimidin-2-yl)-dimethyl-amine (0.87 g). (2-chloro-pyrimidin-4-yl)-dimethyl-amine; CI MS m/e 158, M + For : 1H NMR (300 MHz, CDC13) 8 3.12 (s, 6 H), 6. 32 (d, J= 6.1 Hz, 1 H), 8.00 (d, J = 6.1 Hz, 1 H). (4-chloro-pyrimidin-2-yl)-dimethyl-amine ; ESI MS m/e 157, M> ;’H NMR (300 MHz, CDCI3) No. 3. 21 (s, 6 H), 6.50 (d, J= 5.1 Hz, 1 H), 8.18 (d, J= 5. 1 Hz, 1 H).
With the rapid development of chemical substances, we look forward to future research findings about 3934-20-1.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc; WO2005/95357; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia