The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3934-20-1, name is 2,4-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2,4-Dichloropyrimidine
General procedure: A mixture of 2,4-dichloropyrimidine (6.71 mmol), ary-boronic acid (6.71 mmol). DMF or dioxane (10 ml) was added to the above mixture followed by aqueous sodium carbonate (2 M, 6 ml,). The reaction mixture was degassed with argon for 15 min. Pd(PPh3)4 (50 mg, 0.17 mmol) was added and again degassed 5 min. The reaction mixture was maintained at rt for 12 h. The mixture was subsequently filtered and the remaining solid was washed with EtOAc. The filtrate was washed again with water and brine. The organic layer was separated, dried with anhydrous Na2SO4 and filtered. The organic layer was purified by silica gel column chromatography to give the desired product.
With the rapid development of chemical substances, we look forward to future research findings about 3934-20-1.
Reference:
Article; Toviwek, Borvornwat; Suphakun, Praphasri; Choowongkomon, Kiattawee; Hannongbua, Supa; Gleeson, M. Paul; Bioorganic and Medicinal Chemistry Letters; vol. 27; 20; (2017); p. 4749 – 4754;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia