Electric Literature of 39906-04-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.
4-Chloro-6-(4-methoxy-phenyl)-2-methyl-pyhmidin-5-ylamine (Intermediate compound6}To a solution of commercially available 5-amino-4,6-dichloro-2- methylpyrimidine (6.000 g, 33.7038 mmol) in DME (50 ml) and water (10 ml), 4- methoxy phenyl boronic acid (5.122 g, 33.7038 mmol) and sodium carbonate (7.144 g, 67.4076 mmol) were added. The reaction mixture was degassed and kept under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichloride (1.183 g, 1.6852 mmol) was added and the resulting reaction mixture, heated at 9O0C for 3 hours, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a residue (-6 g), which eluted through silica gel with 4% AcOEt in hexane gave 4.503 g (-75% yield) of the pure title compound as a yellow solid.
According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia