As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83774-13-4, name is 4-Chloro-6-isopropoxypyrimidine, molecular formula is C7H9ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines
Production Example 1; In 0.5 ml of tetrahydrofuran was suspended 0.02 g of sodium hydride (60% in oil), to which 0.1 ml of a solution containing 0.02 g of 2-butyn-1-ol in tetrahydrofuran was added dropwise at room temperature. After stirring at room temperature for 20 minutes, 0.1 ml of a solution containing 0.05 g of 4- chloro-6- (isopropyloxy) pyrimidine in tetrahydrofuran was added dropwise at room temperature, followed by stirring for 2 hours. The mixture was then poured into a saturated aqueous ammonium chloride solution, which was extracted three times with t-butyl methyl ether. The combined organic layers were washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated. The residue was subjected to silica gel column chromatography to give 0.05 g of 4- (2- butynyloxy) -6-isopropoxypyrimidine (the present compound (1)). ‘H-NMR : 1.34 (d, 6H), 1.87 (t, 3H), 4.94 (q, 2H), 5.25-5. 34 (m, 1H), 6.05 (s, 1H), 8.42 (s, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 83774-13-4.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2003/76415; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia