Electric Literature of 3438-48-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3438-48-0, name is 4-Phenylpyrimidine, molecular formula is C10H8N2, molecular weight is 156.18, as common compound, the synthetic route is as follows.
General procedure: A mixture of a 4-substituted pyrimidine (2 mmol), 0.53 g3-(2-bromoacetyl)-2H-chromen-2-one (2 mmol), and anactivated alkyne (2.5 mmol) in 40 cm3 1,2-epoxybutanewas heated at reflux temperature for 24 h. The solvent waspartly removed under vacuum, 10 cm3 of MeOH wasadded and the mixture was left overnight at room temperature.The solid formed was filtered, washed on the filterwith a mixture of MeOH/diethyl ether 1:1 and crystallizedfrom CHCl3/MeOH. Ethyl 3-phenyl-7-(2-oxo-2H-chromen-3-yl)-carbonylpyrrolo[1,2-c]pyrimidine-5-carboxylate(13, C26H18N2O5)Yellow crystals; yield: 0.51 g (58 %); m.p.: 273-275 C; 1HNMR (CDCl3 ? TFA, 300 MHz): d = 1.48 (t, J = 7.1 Hz,3H, CH3), 4.52 (q, J = 7.1 Hz, 2H, CH2), 7.49-7.54, 7.63-7.65, 7.77-7.90 (3 m, 9H, 5 H-Phenyl, 4 H-Coum), 8.39 (s,1H, H-6), 8.45 (s, 1H, H-Coum), 8.61 (s, 1H, H-4), 11.29 (s,1H, H-1) ppm; 13C NMR (CDCl3 ? TFA, 75 MHz):d = 14.2 (CH3), 63.1 (CH2), 112.1 (C-4), 117.4 (C-Coum),126.5 (C-Coum), 127.5, 130.2, 132.6 (C-20, C-30, C-40, C-50C-60), 130.3, 133.9, 135.7 (C-6, 2 C-Coum), 110.5, 118.2,123.9, 124.4, 131.4, 140.1, 145.9, 154.6 (C-3, C-4a, C-5, C-7, C-10, 4 Cq-Coum), 143.9 (C-1), 148.9 (C-Coum), 164.0(CO2Et), 180.4 (CO-Coum) ppm; IR (KBr): v = 1728,1698, 1630, 1613, 1525, 1477, 1355, 1258, 1210 cm-1.
Statistics shows that 3438-48-0 is playing an increasingly important role. we look forward to future research findings about 4-Phenylpyrimidine.
Reference:
Article; Popa, Marcel M.; Georgescu, Emilian; Draghici, Constantin; Georgescu, Florentina; Dumitrascu, Florea; Dumitrescu, Denisa; Monatshefte fur Chemie; vol. 146; 12; (2015); p. 2029 – 2040;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia