Synthetic Route of 39906-04-2 , The common heterocyclic compound, 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 1 (800 mg, 4.48 mmol) and benzenamine (510 mg, 5.44 mmol) were suspended in EtOH/H2O (30 mL, 1:8). Concentrated hydrochloric acid (0.5 mL) was added at room temperature followed by warming reaction to reflux. After stirring for 10 h the reaction was cooled to room temperature and stirred for 6 h. The precipitate was collected on a sintered glass funnel and rinsed with water (10 mL) followed by hexanes (10 mL). After drying in vacuo, Compound 2a (850 mg) was obtained. Yield: 81%; gray solid. MS (EI) m/z (%)=234 (M+).
The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xu, Dan; Sun, Li-Ping; You, Qi-Dong; Tetrahedron; vol. 68; 22; (2012); p. 4248 – 4251;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia