Adding a certain compound to certain chemical reactions, such as: 1211522-68-7, 4,6-Dichloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
4,6-Dichloro-3-methyl-1H-pyrazolo [3,4-d] pyrimidine(70 mg, 0.34 mmol) was added to ethyl acetate (2 mL), and dihydropyran (0.2 mL, 2.3 mmol) and p-toluenesulfonic acid (3 mg) were added. The mixture was stirred at 50 C for 12 hours. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate and water, and the organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The concentrate was subjected to column chromatography to obtain the target compound. (30 mg, 54%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1211522-68-7, 4,6-Dichloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Korea Research Institute of Chemical Technology; Cho Seong-yun; Kim Pil-ho; Lee Jeong-ok; Kim Hyeong-rae; Ha Jae-du; Jeong Hui-jeong; Yoon Chang-su; Park Ji-hun; Hwang Jong-yeon; (76 pag.)KR2018/137057; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia