Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4994-86-9, name is 4-Chloro-2-methylpyrimidine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H5ClN2
To a stirred solution of 4-chloro-2-methylpyrimidine (81 .1 mg, 631 pmol), and cyclopropyl(4-{[2-{[6-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yI)-1 H-benzimidazol-2-yl]amino}-6-(trifluoromethyl)pyridin-4-yl]methyl}piperazin-1 -yl)methanone (200 mg, 351 pmol) in Dioxane(1.7 mL) and water (340 p1) was added sodium carbonate (111 mg, 1.05 mmol) andPd(dppf)C12 . CHCl (42.9 mg, 52.6 pmol). The mixture was heated to reflux for 19 h.Dichloromethane was added, the mixture was filtered and, the solvent was removed invacuum. Preparative reverse phase HPLC (gradient of water and acetonitrile containing ammonia as additive) gave 20.0mg (10 % yield) of the title compound.LC-MS (Method 2): R = 1.16 mm; MS (ESipos): m/z = 537 [M+H]1H-NMR (400 MHz, CHLOROFORM-d) oe [ppm]: 0.725 (4.36), 0.951 (5.34), 1.261 (1.93), 1.284(6.51), 1.648 (2.11), 2.388 (3.45), 2.793 (3.68), 2.845 (16.00), 3.560 (7.24), 7.582 (2.62), 7.985 (1.62), 8.348 (0.99), 8.675 (3.91), 8.688 (3.75), 11.977 (2.41).
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Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; PRINZ, Florian; LEFRANC, Julien; SCHROeDER, Jens; MENGEL, Anne; BONE, Wilhelm; BALINT, Joszef; WENGNER, Antje; EIS, Knut; IRLBACHER, Horst; KOPPITZ, Marcus; BOeMER, Ulf; BADER, Benjamin; BRIEM, Hans; LIENAU, Philip; CHRIST, Clara; STOeCKIGT, Detlef; HILLIG, Roman; (1256 pag.)WO2017/102091; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia