Reference of 56621-90-0, Adding some certain compound to certain chemical reactions, such as: 56621-90-0, name is 5-Amino-2-chloropyrimidine,molecular formula is C4H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56621-90-0.
A mixture of 5-Amino-2-chloro-pyrimidine (4.5 g, 34.9 mmol), 3- TRIFUOROMETHYLPHENYLBORONIC acid (9.9 g, 52.3 MMOL), Pd (OAc) 2 (390 MG, 1.74 MMOL), DPPF (963 mg, 1.74 MMOL), 2 M aqueous K2C03 (52 mL), and toluene (100 mL) were heated at 110 C for 16 h. The mixture was diluted with EtOAc (100 mL) and the organic layer washed with H20 (100 mL) and brine (100 mL). Drying (MgS04) and removal of the volatiles in-vacuo gave a dark brown solid. Chromatography of this material on silica gel using a Hexanes/EtOAc gradient (20% EtOAc to 80% EtOAc) gave 3 as a colorless solid (3.5 g, 14.6 MMOL, 41% yield, M/Z + = 240. 1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56621-90-0, 5-Amino-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CYTOKINETICS, INC.; WO2005/5382; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia