Application of 1480-96-2, Adding some certain compound to certain chemical reactions, such as: 1480-96-2, name is 5-Fluoro-2-methoxypyrimidin-4(3H)-one,molecular formula is C5H5FN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1480-96-2.
500 g of methanol was placed in a constant-temperature reaction bath, and hydrogen chloride gas was introduced until the methanol increased weight to 543 g-556 g to stop aeration. The prepared methanol solution of hydrogen chloride was placed in a refrigerator for use.In a dry and clean 500 mL four-neck flask, 250 g of hydrochloric acid in methanol was added, and 50 g of 2-methoxy-5-fluorouracil was stirred. When the temperature was raised to 28 C., incubation was started. After 5 h, samples were taken for HPLC detection. At 0.07%, the reaction was completed, the temperature was lowered to 15C, and the resulting solid was suction filtered.The refined 5-fluorouracil is refined and the mother liquor is concentrated after suction filtrationShrink the recovered methanol for use. The resulting 5-fluorouracil dry weight was 35.4 g, with a purity of 99.82% and a yield of 78.3%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1480-96-2, 5-Fluoro-2-methoxypyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jinghua Pharmaceutical Group Nantong Co., Ltd.; Yuan Yongjun; Shen Xiaojuan; Li Shufen; Chen Xuelian; Wu Yuxiang; (4 pag.)CN107963994; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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