Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 31462-58-5, name is 5-Iodopyrimidine. A new synthetic method of this compound is introduced below., Formula: C4H3IN2
General procedure: Ir[dF(CF3)ppy]2(dtbpy))PF6(5.6 mg, 4.99 mumol) was added to a stirred solution of aryl iodide (1.00 mmol), iminodimethyl-lambda6-sulfanone (102 mg, 1.10 mmol), 4,4′-di-tert-butyl-2,2′-bipyridine (20 mg, 0.07 mmol), TEA (0.279 mL, 2.00 mmol) and NiCl2(glyme) (11 mg, 0.05 mmol) in acetonitrile (5.6 mL). The resulting mixture was irradiated with a blue LED (450 nm, Penn Optical Photoreactor m1) and stirred at 29 C for 16 hours. The reaction mixture was quenched with saturated aqueous NaHCO3(2 mL) and extracted with EtOAc. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure.The resulting residue was purified by flash silica chromatography to afford the corresponding products.
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Reference:
Article; Hande, Sudhir; Mfuh, Adelphe; Throner, Scott; Wu, Ye; Ye, Qing; Zheng, XiaoLan; Tetrahedron Letters; vol. 60; 41; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia