The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 216309-28-3, name is 5-((Trimethylsilyl)ethynyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 216309-28-3
[5-METHYL-3-PYRIMIDIN-5-YL-2- (TRIMETHYLSILYL)-LH-PYRROLOF2, 3-B1PYRIDINE] A mixture of [3-IODO-5-METHYLPYRIDIN-2-AMINE] (2.0 g, 8.64 [MMOL),] bis (triphenylphosphine) palladium (II) chloride [(0. 48] g, 0.58 mmol), [1,] 4-diazabicyclo (2,2, 2) octane (1.66 g, 14.8 [MMOL), 5-[(TRIMETHYLSILYL) ETHYNYL] PYRIMIDINE] (1.97 g, 11.2 mmol) and N, N-dimethylformamide (10 ml) was heated to [110 C] for 16 h. The reaction mixture was evaporated and the crude product was purified by column chromatography (silica gel, ethyl acetate-heptane gradient from 0: 100 to 100: 0) to yield the subtitle compound (0.86 g, 35%). 1H-NMR (400 MHz, DMSO-d6) : [8] 11.75 (s, 1H), 9.40 (s, 1H), 8.83 (s, 2H), 8.16 (d, [J] 1. 7 Hz, 1H), 7.64-7. 62 (m, [1H),] 2.34 (s, 3H), 0.44 (s, 9H). APCI-MS m/z: 283.2 [[MH+].]
With the rapid development of chemical substances, we look forward to future research findings about 216309-28-3.
Reference:
Patent; ASTRAZENECA AB; WO2004/16609; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia