Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50270-27-4, name is 2,4,6-Trichloropyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below., Computed Properties of C5HCl3N2O
At -10 willCompound 3 (100 mg, 0.47 mmol)In methanol was slowly added dropwise to a methanolic solution of hydrazine hydrate (0.024 ml)A solution of triethylamine (0.067 ml) in methanol was then added dropwiseTo the above mixture,Continue at -10 Reaction time 30 min.TLC detection (PE: EA = 2: 1),Raw material reaction is complete,Spin drying solvent,Column chromatography (PE: EA = 10: 1) gaveWhite solid 4 (50 mg), yield 56.3%
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Reference:
Patent; Sichuan Baili Pharmaceutical Co., Ltd.; Wu, Yong; Zhu, Yi; Hai, Li; Wang, Yiqian; Li, Jie; (22 pag.)(2016);,
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