New downstream synthetic route of 5604-46-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Related Products of 5604-46-6 ,Some common heterocyclic compound, 5604-46-6, molecular formula is C5H3Cl2N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2. Procedures for preparation of compound 11; NH2 H NH2 N”‘N 0 H p NN H ci cl (furoic hydrazide) ci H ou compound V CH3CN compound))) Na2CO3 40 Deg. C H0- NH NH2 80 Deg. C Zu NH2 Nu2 Nf H (at) N”S compound 11 Compound V (1. 0g, 1. Oeq.), 2-furoic hydrazide (0.7g, 1. 1 eq.) and sodium carbonate (0.55g, 1. Oeq. ) were added acetonitrile (20mL) and was heated to 40C. After stirring at 40C for 30 hours, the reaction was subsequently heated to 60C. A solution of 2- hydroxyethyl hydrazine (0.7mL, 2eq. ) in water (5mL) was added. The reaction mixture was then heated to 80C and stirred for 2.5 hours. Once the reaction was completed, the reaction mixture was cooled down to 25C, and 0.1 N HCI (10mL) was added. The reaction mixture was stirred at 25C for 2 hours. The reaction mixture was then concentrated to about 1 OmL under reduced pressure. Water (30mL) was added and the reaction mixture was concentrated to about 1 OmL under reduced pressure. The reaction mixture was stirred at 25C for overnight. The solid was filtered and washed with 2mL water, then with 2mL acetonitrile. The product (compound 1) was dried under vacuum at 25C to yield 1. 1 g (70%) of the desired product. LC/MS: m/z=304 (M+1) 1H NMR (DMSO-d6) : 610. 65 (d, 1H) ; 9.52 (d, 1H) ; 7.98-7. 88 (m, 1H) ; 7.42-7. 29 (m, 1H) ; 6.73-6. 70 (m, 1H) ; 6.35 (s, 2H); 4.9 (s, 1H) ; 4.1 (m, 2H); 3.62 (m, 2H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SCHERING CORPORATION; WO2005/54245; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia