Reference of 5751-20-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one, molecular formula is C5H6N2OS, molecular weight is 142.18, as common compound, the synthetic route is as follows.
2-(Methylthio)pyrimidin-4(3H)-one (3 g, 21 mmol) and 4-aminobenzonitrile (2.99 g, 25 mmol) were weighed in a 50 mL round bottom flask.Nitrogen protection,Slowly warm up to 180 ¡ã C,Reaction 8h.After the reaction was cooled, it was sonicated by adding 20 mL of acetonitrile, filtered, and the filter cake was washed with acetonitrile, and the residue of 4-aminobenzonitrile was not detected by TLC, and the cake was dried to give a pale yellow solid which was 4-((4-oxo-1,6) – dihydropyrimidin-2-yl)amino)benzonitrile, yield 73.6percent,
The chemical industry reduces the impact on the environment during synthesis 5751-20-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shandong University; Liu Xinyong; Zhou Zhongxia; Zhan Peng; (32 pag.)CN109369623; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia