Electric Literature of 873-83-6 ,Some common heterocyclic compound, 873-83-6, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of 4-aminocoumarin /6-aminouracil (1.0 mmol), isatin/5-bromoisatin (1.0 mmol), 1,3-diketo compound (cyclohexane-1,3-dione, indane-1,3-dione, dimedone, 1,3-dimethylbarbituric acid)(1.0 mmol) and PEG?OSO3H (15 molpercent) was taken in 5 ml water. The mixture was stirred at 70 oC for a required period of time (TLC). After completion of each reaction, the crude product (insoluble in water) was filtered and it was washed with ethanol. The isolated product was recrystallized from DMF?water to get the pure product.#10;#10;#10;
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-83-6, its application will become more common.
Reference:
Article; Paul, Sanjay; Das, Asish R.; Tetrahedron Letters; vol. 54; 9; (2013); p. 1149 – 1154;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia