New downstream synthetic route of 6-Bromo-4-chloropyrido[2,3-d]pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1215787-31-7, 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1215787-31-7, name is 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, molecular formula is C7H3BrClN3, molecular weight is 244.4758, as common compound, the synthetic route is as follows.Formula: C7H3BrClN3

Add 24.2 g (0.1 mol) of 4-chloro-6-bromopyrido[2,3-d]pyrimidine, 7.4 g (0.1 mol) of propylenediamine and 400 ml of 1,4-dioxane to a 1 L round bottom flask. The mixture was heated to 60 C, and the reaction was monitored by TLC until the reaction was completed, and the solvent was evaporated to givethe compound 8-1 18.9 g of white solid (yield: 79.8%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1215787-31-7, 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Heilongjiang University Of Traditional Chinese Medicine; Chen Hong; Chen Qun; Li Yan; Liu Yan; Song Qiannan; Wang Lin; Su Yuming; Liu Linlin; Dai Jinzhu; Guo Jianbo; Li Fei; Lu Lu; Guo Wei; (18 pag.)CN109836423; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia