Adding a certain compound to certain chemical reactions, such as: 4316-98-7, 6-Chloro-4,5-diaminopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 6-Chloro-4,5-diaminopyrimidine, blongs to pyrimidines compound. Application In Synthesis of 6-Chloro-4,5-diaminopyrimidine
1.6 g of the 2-(N-methylmethylsulfonamide)nicotinic acid obtained in this way are suspended in 10 ml of dichloromethane, and 0.6 ml of thionyl chloride is added dropwise. This suspension is stirred at 40 C. for 3 h, and, immediately after addition of a few drops of DMF, 3 is reacted further with 1 g of 6-chloropyrimidine-4,5-diamine at RT for 16 h. Removal of the solvent gives a 1:3 mixture of 2.3 g of the regioisomers 4, which are immediately reacted further in 30 ml of POCl3 at 50 C. in 48 h to give 5. Chromatography with dichloromethane/methanol=100:0->90:10 gives 810 mg of a colourless solid; LCMS: 339.0 (M+H), RT. 1.341 min.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4316-98-7, 6-Chloro-4,5-diaminopyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK PATENT GMBH; Heinrich, Timo; Rohdich, Felix; Esdar, Christina; Krier, Mireille; Greiner, Hartmut; US2015/218155; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia