Synthetic Route of 69696-37-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69696-37-3, name is 5-Bromo-2,4-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
g) methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)quinolin-4-yl)amino)-5- isopropoxybenzoate. A mixture of methyl 3-((7-bromo-3-carbamoylquinolin-4- yl)amino)-5-isopropoxybenzoate (300 mg, 0.655 mmol) bis(pinacolato)diboron (183 mg, 0.720 mmol), potassium acetate (225 mg, 2.291 mmol), [1 , 1 – bis(diphenylphosphino)ferrocene]dichloropalladium(ll) dichloromethane adduct (26.7 mg, 0.033 mmol) and 1 ,4-dioxane (3 ml.) was heated at 1 10 C for 45 minutes in a microwave reactor. Cesium carbonate (427 mg, 1 .309 mmol), 5- bromo-2,4-dimethylpyrimidine (0.045 ml_, 0.393 mmol), [1 ,1 – bis(diphenylphosphino)ferrocene]dichloropalladium(ll) dichloromethane adduct (26.7 mg, 0.033 mmol), and water (1 ml.) were added and the mixture heated again in a microwave reactor at 1 10 C for 1 hour. LCMS indicated formation of the desired product. The mixture was filtered and purified by reverse-phase preparative HPLC (ODS, acetonitrile/0.03% aqueous ammonia) to afford the title compound (150 mg, 47%). LCMS (ES+) m/e 486 [M+H]+.
According to the analysis of related databases, 69696-37-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas; WO2013/96151; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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