The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 90213-66-4
Intermediate 46; 2,4-Dichloro-7-methyl-7H-pyrrolor2,3-d1pyrimidine 103496-1P2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (2370 mg, 12.61 mmol) was dissolved in acetonitrile (8320 mul) and sodium hydride (529 mg, 13.24 mmol) was added portion- wise. The reaction mixture was stirred at room temperature for 30 minutes until gas evolution ceased. Methyl iodide (867 mul, 13.87 mmol) was added and the resulting mixture was stirred for 30 minutes. The reaction mixture was then poured into water and extracted with DCM/MeOEta. Concentration of the organic layers under reduced pressure provided a residue, which was purified utilizing ISCO (0%-? 100% DCM/EtOAc) to afford the title product (2. Ig). LCMS: 204 [M+Eta]+.
Statistics shows that 90213-66-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin; WO2010/38060; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia