Electric Literature of 22536-65-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22536-65-8, name is 2-Chloro-5-methoxypyrimidine, molecular formula is C5H5ClN2O, molecular weight is 144.56, as common compound, the synthetic route is as follows.
To a mixture of 2-chloro-5-methoxypyrimidine (1.5 g), 2-(2-fluoro-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolan (2.5 g), a 2 M sodium carbonate aqueous solution (11 mL), and DME (10 mL) was added tetrakistriphenylphosphinepalladium(0) (500 mg) under nitrogen atmosphere. The resulting mixture was heated with stirring at 80¡ã C. for 3 hours. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The resulting organic layers were washed with saturated brine, and dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residues were subjected to silica gel chromatography to give the Intermediate compound 1 represented by the following formula (2.0 g).
The chemical industry reduces the impact on the environment during synthesis 22536-65-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sumitomo Chemical Company, Limited; ORIMOTO, Kohei; NOKURA, Yoshihiko; NAKAJIMA, Yuji; TANABE, Takamasa; (52 pag.)US2018/317485; (2018); A1;,
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