Electric Literature of 1224944-77-7 ,Some common heterocyclic compound, 1224944-77-7, molecular formula is C9H8ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate (677 mg, 3.00 mmol), Nmethylmethanamine hydrochloride (489 mg, 6.00 mmol) and N,N-diisopropylethylamine (1 .6 ml, 9.0 mmol) in 2-propanol (20 ml) was refluxed for 5 h. Upon cooling, ice water was added and the mixture was extracted with ethyl acetate (3x). The combined organic phases were filtrated through a silicone filter and concentrated to give the title compound (674 mg).[C-MS (Method 1): R = 0.84 mm; MS (ESIpos): m/z = 235 [M+H]1H-NMR (400 MHz, DMSO-d6) 6 [ppm]: 1.261 (7.26), 1.278 (16.00), 1.296 (7.57), 3.182(14.34), 4.157 (2.25), 4.175 (7.19), 4.193 (7.07), 4.211 (2.14), 6.691 (4.60), 6.710 (4.61),8.181 (9.13), 8.673 (5.48), 8.693 (5.36).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1224944-77-7, Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia