Application of 1421372-94-2 ,Some common heterocyclic compound, 1421372-94-2, molecular formula is C20H16FN5O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(l- methyl-1 H-indol-3 -yl)pyrimidin-2-amine (200 mg, 0.508 mmol) and diisopropylethylamine (0.328 mg, 2.54 mmol) in dimethyl sulfoxide (4 mL) was added 3-((dimethylamino)methyl)- N-methylbicyclo[l . l. l]pentan-l-amine (117 mg, 0.762 mmol). The mixture was heated at 100 “C for 24 h. The mixture was cooled to RT and diluted with dichloromethane and water. The organic layer was separated, dried over Na2S04 and concentrated in vacuo. The crude product was purified by HPLC (10:90 to 80:20 0.1% HC02H (aq):MeCN) to afford Nl-(3- ((dimethylamino)methyl)bicyclo[ 1.1.1 Jpentan- 1 -yl)-5-methoxy-Nl -methyl-N4-(4-(l -methyl- lH-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-l,4-diamine (140 mg, 52%). LC/MS (ESI) m/z 528.6 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1421372-94-2, N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; KALYRA PHARMACEUTICALS, INC.; BUNKER, Kevin, Duane; HUANG, Peter, Qinhua; ABRAHAM, Sunny; PINCHMAN, Joseph, Robert; HOPKINS, Chad, Daniel; SLEE, Deborah, Helen; (93 pag.)WO2017/205459; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia