Related Products of 1500-85-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1500-85-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Scheme 3 NH2 NPhth XN phthalic anhydride XN N N DMAC N N H H 3-1 3-2 H H 3J. 32 To a 250 mL three-neck round bottom flask equipped with an overhead stirrer, nitrogen inlet, and thermocouple was charged 50 mL of dry N,N-dimethylacetamide followed by 5.0 g OF 7H-PYRROLO [2, 3-DLPYRIMIDIN-4-YLAMINE (U) [J. Davoll, J. Chem. SOC., 131-138 (1960)] and 11.6 g of phthalic anhydride. The resulting mixture was heated to 80 C for 8 h and then cooled to 10 C. Water (40 ML) was added while maintaining the temperature below 15 C. The resulting slurry was aged for 4 h, then filtered, and the filter washed with 20 ML of 1: 1 (v/v) dimethylacetamide/water followed by 30 ML of water. The cake was sucked dry, then washed with 50 ML of ethyl acetate. The solid was dried at 40 C under vacuum with a nitrogen sweep to give 8.1 g OF 4-PHTHALIMIDO-7H-PYRROLO [2, 3-d]pyrimidine (3-2); m. p. 276-277 C. LH NMR (DMSO-D6, 400 MHz) : 8 12. 14 (s, 1H), 8.79 (s, 1H), 8.01 (dd, J=5.5, 3.1 Hz, 2H), 7.92 (dd, J=5. 5,3. 1 HZ, 2H), 7.63 (dd, J=3.5, 2.4 Hz, 1H), 6.56 (dd, J=3.5, 1.8 Hz, 1H) ; 13C NMR (DMSO-D6, 100 MHZ) : 5 166.3, 154.2, 151.0, 145. 2,135. 7,132. 0,128. 7,124. 4,115. 2,100. 1.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1500-85-2, 7H-Pyrrolo[2,3-d]pyrimidin-4-amine.
Reference:
Patent; MERCK & CO. INC.; WO2004/72090; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia