Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4983-28-2, Name is 2-Chloro-5-hydroxypyrimidine, molecular formula is C4H3ClN2O, belongs to pyrimidines compound. In a document, author is Esteban-Parra, Gines M., introduce the new discover, Safety of 2-Chloro-5-hydroxypyrimidine.
Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5-alpha] pyrimidine ligand
We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1,2,4-triazolo[1,5-alpha] pyrimidine (7-amtp), and a new family of coordination compounds based on this ligand and zinc as metal ion, synthesized by conventional routes. These materials possess different mononuclear structures, namely [ZnCl2(7-amtp)(2)] (1), [Zn(7-amtp)(2)(H2O)(4)](NO3)(2)2(7-amtp)6H(2)O (2) and [Zn(7-amtp)(2)(H2O)(4)](SO4)1.5H(2)O (3) derived from the use of different zinc (II) salts, in such a way that the counterions govern the crystallization to a large extent. These compounds present and show variable luminescent properties based on ligand-centred charge transfers which have been deeply studied by Time Dependent Density Functional Theory (TD-DFT) calculations. When these compounds are transferred to solution, preserving complex entities as corroborated by NMR studies, they present interesting anti-diabetic and anti-parasitic capabilities, with a comparatively higher selectivity index than other previously reported triazolopyrimidine-based materials. The results derived from in vivo experiments conducted in mice also confirm their promising activity as anti-diabetic drug being capable of dropping glucose levels after oral administration. Therefore, these new materials may be considered as excellent candidates to be further investigated in the field of luminescent coordination compounds with biomedical applications.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4983-28-2. Safety of 2-Chloro-5-hydroxypyrimidine.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia