The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methylfuran-2(3H)-one( cas:591-12-8 ) is researched.Formula: C5H6O2.Romaniszyn, Marta; Sieron, Leslaw; Albrecht, Lukasz published the article 《Asymmetric vinylogous Michael addition of 5-substituted-furan-2(3H)-ones to an α,β-unsaturated-γ-lactam》 about this compound( cas:591-12-8 ) in Organic & Biomolecular Chemistry. Keywords: butenolide pyrrolidinone preparation enantioselective chemoselective; furanone unsaturated lactam asym vinylogous Michael addition quinine squaramide. Let’s learn more about this compound (cas:591-12-8).
The manuscript describes an utilization of 5-substituted-furan-2(3H)-ones as pronucleophiles in an asym. vinylogous Michael addition to an α,β-unsaturated-γ-lactam, thus leading to hybrid mols. possessing γ-lactam and butenolide structural motifs. The transformation utilizes two potentially vinylogous pronucleophiles and has been realized by simultaneous activation of both substrates by a bifunctional organocatalyst derived from a cinchona alkaloid. Reaction occurs in a highly enantio- and diastereoselective manner and the synthetic potential of the target products has been confirmed in stereoselective transformations.
In some applications, this compound(591-12-8)Formula: C5H6O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia