Adding a certain compound to certain chemical reactions, such as: 1012785-51-1, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1012785-51-1, blongs to pyrimidines compound. Application In Synthesis of 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
[00491] A mixture of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-djpyrimidine (0.66 g, 2.1 mmol, 1.0 eq), 4- methylbenzenesulfonyl chloride (0.46 g, 2.4 mmol, 1.1 eq), triethylamine (0.40 mL, 29 mmol, 1.4 eq), and DMAP (0.033 g, 0.27 mmol, 0.13 eq) in 4 mL of dichloromethane was stirred at room temperature for 1 hr. The reaction mixture was diluted with dichloromethane and washed with iN HC1 (2X), followed by a wash with saturated aqueous sodium bicarbonate. The worked-up solution was dried over MgSO4, filtered, rotary evaporated, and dried under vacuum giving 1.1 g of yellow solid as the crude 2,4-dichloro-5-iodo-7-tosyl- 7H-pyrrolo [2,3 -d]pyrimidine. LC-MS: M+H=467. 7.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1012785-51-1, its application will become more common.
Reference:
Patent; PHARMACYCLICS LLC; CHEN, Wei; JIA, Zhaozhong, J.; THOMAS, William, D.; WONE, David; (190 pag.)WO2017/205762; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia