Adding a certain compound to certain chemical reactions, such as: 1439-10-7, 4-Amino-5-bromopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1439-10-7, blongs to pyrimidines compound. SDS of cas: 1439-10-7
The above boronate (0.2 g) was dissolved in DME: H20 (5 mL: 1 mL). 2-Amino-3-bromo- pyrimidine (0.070 g) and potassium carbonate (0.092 g) were added and the flask was flushed with N2. The mixture was stirred for 20 min, and then PDCL2 (DPPF) CH2CL2 (0.020 g) was added. The mixture was heated at 80 C for 2h, cooled to room temperature and diluted with EtOAc. The mixture was filtered, concentrated and the residue was purified by silica gel chromatography to afford the title compound (0.080 g) as a foam (713.3, M+1)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1439-10-7, 4-Amino-5-bromopyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2004/41273; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia