The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. SDS of cas: 145783-14-8, 145783-14-8, Name is 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine, SMILES is CCCSC1=NC(Cl)=C([N+]([O-])=O)C(Cl)=N1, in an article , author is Rani, Nallamothu Vanaja, once mentioned of 145783-14-8.
PEG-400 promoted a simple, efficient and eco-friendly synthesis of functionalized novel isoxazolyl pyrido[2,3-d]pyrimidines and their antimicrobial and anti-inflammatory activity
A simple, efficient, cost-effective and environmentally friendly synthesis of new isoxazolyl pyrido[2,3-d]pyrimidine derivatives 11 has been developed from 4-amino-3-methyl-5-styrylisoxazoles 7 by using polyethylene glycol-400 (PEG-400) as a solvent as well as catalyst. Compound 7 on treatment with methyl-2-chloronicotinate 8 in the presence of PEG-400 to obtain the corresponding (E)-methyl-2-((3-methyl-5-styrylisoxazol-4-yl)amino)nicotinates 9, which was further treated with different arylisothiocyanates 10 in the presence of PEG-400 under heating condition afforded the target products isoxazolyl pyrido[2,3-d]pyrimidines 11 in good to excellent yields. The target compounds 11a-y was also evaluated for their antimicrobial and anti-inflammatory activities. Among the tested compounds, the compounds 11w, 11x, and 11y showed significant antimicrobial activity and potent anti-inflammatory activity as that of standard drugs. The superiority of this method is catalyst free, operational simplicity, environmental safety; metal free, broad substrate scope, easy purification, high yields and PEG-400 can be recovered and reused.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 145783-14-8, you can contact me at any time and look forward to more communication. SDS of cas: 145783-14-8.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia