The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 147118-37-4, name is N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide. This compound has unique chemical properties. The synthetic route is as follows. 147118-37-4
Methyl magnesium chloride solution (3M) (11.87 ml, 0.0356 moles) in tetrahydrofuran was added to a pre-cooled suspension of pyrimidine carboxaldehyde (5 g, 0.0142 moles) in anhydrous tetrahydrofuran (30 ml) under stirring for 30 min at 0-5 C. The reaction mass was stirred at the same temperature. After completion of the reaction, the reaction mass was poured into pre-cooled saturated ammonium chloride solution (100 ml) at 0-5 C. and stirred for 1 h at 5-10 C. The product was extracted into ethyl acetate (150 ml) and washed with saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was distilled under vacuum at 40-45 C. until the traces of ethyl acetate were completely removed to give the title compound.
Statistics shows that 147118-37-4 is playing an increasingly important role. we look forward to future research findings about N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide.
Reference:
Patent; Mallela, Sambhu Prasad Sarma; Nandi, Sakumar; Nangi, Gangadhara Bhima Shankar; Ananta, Rani; Meenakshiunderam, Sivakumaran; US2011/178296; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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