In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1558-17-4, name is 4,6-Dimethylpyrimidine, the common compound, a new synthetic route is introduced below. Quality Control of 4,6-Dimethylpyrimidine
Example 24, 25 To a solution of 4,6-dimethylpyrimidine (1.08 g, 10 mmol) in THF (40 ml) was added dropwise at -78 C a solution of n-butyllithium. To the solution was added benzylbromide (1.71 g, 10 mmol). The mixture waswarmed up to 0 C and stirred for 30 minutes. To the reaction mixture was added an aqueous solution of ammonium chloride. The mixture was extracted with ethyl acetate, washed with water, dried and concentrated. The obtained residue was chromatographed on silica gel (n-hexane-ethyl acetate). The obtained fraction was concentrated to give 4-methyl-6-phenethylpyrimidine (1.7 g). Compound (I-24) and (I-25) were prepared from the above-obtained 4-methyl-6-phenethylpyrimidine in accordance with Example 2 and 3. Compound (I-24) 1H-NMR(CDCl3) delta: 1.40(3H,t,J=7.1Hz), 3.06(4H,s), 4.35(2H,q,J=7.1Hz), 6.39(1H,s), 6.86(1H,s), 7.12-7.35(6H,m), 8.95(1H,s). Compound (1-25) 1H-NMR(d6-DMSO) delta: 3.00(4H,s), 6.29(1H,s), 7.15-7.40(6H,m), 8.92(1H,s).
The synthetic route of 1558-17-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHIONOGI & CO., LTD.; EP1219607; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia