Application of 15846-19-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15846-19-2, name is 4-Chloro-6-methoxypyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.
Example P1 Preparation of STR6 N-(3′-Chloro-2′,6′-dinitro-4′-trifluoromethylphenyl)-5-amino-4-chloro-6-methoxypyrimidine 2.84 g (17.8 mmoles) of 5-amino-4-chloro-6-methoxypyrimidine are dissolved in 20 ml of dimethylsulfoxide. With stirring, a solution of 6.24 g (20.5 mmoles) of 1,3-dichloro-2,6-dinitro-4-trifluoromethylbenzene in 15 ml of dimethylsulfoxide and a solution of 2.30 g (20.5 mmoles) of potassium tert-butylate in 15 ml of dimethylsulfoxide are added simultaneously dropwise at 15 C. The dark red solution so obtained is stirred for 1 hour at 15-20 C. and then poured into ice-water, neutralised with acetic acid and extracted three time with chloroform. The extracts are dried over sodium sulfate and the solvent is removed by rotary evaporation, affording 7.9 g of an oil. This crude product is purified by chromatography through a column of silica gel affording 3.19 g of a crystalline product. Recrystallisation from a mixture of 2 ml of toluene and 8 ml of cyclohexane yields 2.52 g of yellow crystals of m.p. 114-116 C.
According to the analysis of related databases, 15846-19-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ciba-Geigy Corporation; US4840662; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia