Reference of 16234-14-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16234-14-3 as follows.
2-Chlorothieno[3,2- Pd/C (8.90 mg, 20%> by wt) was added after 12 h. The reaction mixture was filtered through Celite with EtOAc washings. The filtrate was washed with H20/brine (4:1), dried (MgS04), and concentrated under reduced pressure to provide 16 (33.0 mg, 90%) as white solid: Mp 164.9-165.5 C (EtOAc); IR (ATR, neat) 3105, 3051, 2924, 1543, 1515, 1456, 1420, 1334, 1349, 1301, 1159, 794 cm”1; 1H NMR (DMSC fe 300 MHz) delta 9.50 (s, 1 H), 8.64 (d, 1 H, J= 5.4 Hz), 7.64 (d, 1 H, J= 5.4 Hz); 13C NMR (DMSO-d6, 75 MHz) delta 162.7, 156.3, 155.3, 142.2, 130.1, 122.9; MS (EI) m/z 170 (M+, 100), 135 (72);HRMS (EI) m/z calcd for C6H3N2SC1 169.9705, found 169.9700.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16234-14-3, its application will become more common.
Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; WANG, Qiming, Jan; WO2012/78859; (2012); A2;,
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