Application of 175791-49-8 , The common heterocyclic compound, 175791-49-8, name is 5-Bromo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 5-bromo-7H-pyrrolo[2,3-d]pyrimidine (1, 0.9 g, 4.54 mmol) in tetrahydrofuran (10 mL) at 0 C., was added sodium hydride (0.27 g, 6.81 mmol, 60% in hexane). The reaction mixture was allowed to stir at 0 C. for 20 min. Chloromethyl 2-trimethylsilylethyl ether (0.9 g, 5.44 mmol) was then added and the reaction mixture was stirred at 0 C. for an additional 30 min., and then quenched with water. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography using 5% methanol in dichloromethane to afford 5-bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (2). Yield: 1.3 g, 86%; MS (ESI) m/z 328[M+1]+.
The synthetic route of 175791-49-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EFFECTOR THERAPEUTICS, INC.; Sprengeler, Paul A.; Reich, Siegfried H.; Ernst, Justin T.; Webber, Stephen E.; (55 pag.)US2017/121339; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia