Electric Literature of 1820-81-1 , The common heterocyclic compound, 1820-81-1, name is 5-Chlorouracil, molecular formula is C4H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
1-(2′,3′,4′,6′-tetra-O-Acetyl-b-D-glucopyranosyl)-5-chlorouracil (12b). 12b (1.14 g,93%) was obtained as a white amorphous under the following conditions: 5-chlorouracil (487.5 mg, 3.33 mmol), HMDS (3.5 mL), pyridine (1.7 mL), reflux, 30 min.N-Glycosylation: 2b (3.33 mmol), MeCN (25 mL), 11 (1.00 g, 2.56 mmol), 7b (80.5mg, 0.26 mmol, 10 mol%), reflux, 24 h, purification by MPLC (size 120, EtOAc_hexane= 0:100 50:50).
The synthetic route of 1820-81-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shirouzu, Hiroshi; Morita, Hiroki; Tsukamoto, Masaki; Tetrahedron; vol. 70; 22; (2014); p. 3635 – 3639;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia