Synthetic Route of 302964-08-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 302964-08-5, name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide. This compound has unique chemical properties. The synthetic route is as follows.
A suspension of intermediate 3 (90 g, 1 equivalent) in DMSO (630 ml, 7 volumes) was heated to 60-650C. To this solution, HEP (89 g, 3 equivalents) was added until the reaction mixture became clear. Heating was continued at the same temperature for 6 hours (reaction was monitored by TLC and HPLC). Then the reaction mixture was allowed to cool to 25- 300C and dichloromethane (1890 ml, 21 volumes) was added, followed by the addition of water (1800 ml, 20 volumes). The mixture was stirred for 1 hour until a white precipitate appeared. The white solid was separated by filtration and dried under suction for 15-20 minutes. The solid was dried in a vacuum oven at 60-650C for 8-12 hours. The white solid obtained weighed 125 g and had a purity (by HPLC) of 99.6%. The solid was determined by XRPD analysis to be dasatinib DCM solvate (see Figure 1).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide.
Reference:
Patent; GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; GORE, Vinayak Govind; PATKAR, Laxmikant; BAGUL, Amit; VIJAYKAR, Priyesh Surendra; EDAKE, Mahesh; WO2010/139979; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
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