Reference of 1683-75-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1683-75-6, name is 2-Amino-4-chloro-5-fluoropyrimidine, molecular formula is C4H3ClFN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The reaction bottle was added with mechanical stirring, and then SM4 (200.0g, 0.666mol) and SM6 (98.0g, 0.666mol) were added in sequence.Palladium acetate (7.4g, 0.033mol), tripotassium phosphate trihydrate (354.0g, 1.332mol), 1,4-dioxane (1.4L) and water (0.6L).Under nitrogen protection, the reaction liquid was heated to 100C, kept under heat and stirred for 4 hours, and the final control of the sampling was completed.The reaction solution was cooled to room temperature, the layers were separated, the organic phase was concentrated, and concentrated hydrochloric acid (250 mL) was added to the concentrated residue.Water (750 mL) and activated carbon (10.0 g) were stirred at room temperature for 1 hour.Filtration, the filtrate was reduced to 0 ~ 5 , then 20% aqueous sodium hydroxide solution (1.0 L) was added dropwise, stirred, filtered,After drying, 163.0 g of light yellow solid was obtained with a yield of 85.8% and a purity of 96.8%.
According to the analysis of related databases, 1683-75-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Liu Fuping; Zhang Jingtao; Wu Liyuan; (48 pag.)CN111138413; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia