Electric Literature of 17321-93-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17321-93-6, name is 2-Amino-5-bromo-4-methylpyrimidine, molecular formula is C5H6BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Isoamylnitrite (21ML) was added to a stirred suspension of 5-bromo-4-methyl-2- PYRIMIDINAMINE (1.75g) in bromoform (30ML) and the mixture heated at 85¡ãC for 4h. After cooling, isohexane (300ML) was added and the solution passed through a pad of silica-gel. The silica was washed with petrol (1000ml), dichloromethane (200ml) then the product eluted with ethylacetate. The ethylacetate layer was evaporated under reduced pressure and the residue purified by chromatography on silica eluting with 5percent diethylether/ isohexane, yield 0. 9g 1H NMR CDC13 : No. 8. 52 (s, 1H), 2.64 (s, 3H) MS: APCI (-VE) 249/51/53
According to the analysis of related databases, 17321-93-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; WO2004/89885; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia