Synthetic Route of 4214-85-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4214-85-1 as follows.
In a 100 mL two-neck round-bottom flask under N2 atmosphereand molecular sieve 3 A was added 2 (2.0 g, 11.7 mmol) in dry DMF (25 mL) and DMF dimethyl acetal (7.5 mL, 70.0 mmol). The mixturewas stirred at 100 C for 24 h and then cooled. The mixturewas dried under vacuum. Acetone (15 mL) was added and theformed precipitate was filtered and washed with acetone (10 mL)furnishing 3 in 96% yield (3.16 g)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4214-85-1, its application will become more common.
Reference:
Article; Rodrigues, Marili V.N.; Barbosa, Alexandre F.; Da Silva, Julia F.; Dos Santos, Deborah A.; Vanzolini, Kenia L.; De Moraes, Marcela C.; Correa, Arlene G.; Cass, Quezia B.; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 226 – 231;,
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