As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine, molecular formula is C4H3BrClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 4-Amino-5-bromo-2-chloropyrimidine
A 100 mL round bottom flask was charged with 5-bromo-2-chloropyrimidin-4- amine (8.0 g, 40 mmol), N,N-diisopropylethylamine (16.0 g, 120 mmol) and tert- butyl piperazine-l-carboxylate (11.0 g, 60 mmol). The resulting mixture was heated at reflux overnight. Work-up: the solvent was evaporated. The residue was re- crystallized from ethanol to afford 9.0 g (65%) of the product as a white solid. MS m/z: 358 (M+H+).
With the rapid development of chemical substances, we look forward to future research findings about 205672-25-9.
Reference:
Patent; KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; NOBLE, Stewart, A.; WO2011/112766; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia