Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 208465-21-8, name is Mesosulfuron-methyl. This compound has unique chemical properties. The synthetic route is as follows. 208465-21-8
Example 25 – 1-(4,6-Dimethoxypyrimidin-2-yl)-3-[2-(hydroxymethyl)-5- (methanesulfonamidomethyl henyl]sulfonyl-urea 8 To a solution of methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-4- (methanesulfonamidomethyl)benzoate (2 g, 3.98 mmol) in THF (30 mL) was added lithium aluminium hydride (755 mg, 19.88 mmol), portionwise, at -20 C. The reaction mixture was warmed to ambient temperature over 1 h, after which time TLC showed complete consumption of the starting material. The reaction was quenched with IPA (5 mL), MeOH (5 mL) and H20 and then acidified to pH 3 with 2 M HCI before being extracted with EtOAc, the organic layer dried over MgS04 and the solvent removed in vacuo. The resulting product was purified by flash chromatography on silica gel (solvent EtOAc) to afford the desired product as a white solid (1.12 g, 59%). 1 H NMR deltaEta (CDCIs, 300 MHz): 9.11 (s, 1 H), 7.90 (s, 1 H), 7.53 – 7.51 (m, 1 H), 7.40 – 7.38 (m, 1 H), 7.24 – 7.20 (m, 1 H), 5.51 (s, 1 H), 4.75 (s, 2H), 4.06 (d, J = 6.0 Hz, 2H), 3.70 (s, 6H), 2.60 (br, 2 H), 2.56, (s 3H). ESI-MS 476.1 [MH]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,208465-21-8, Mesosulfuron-methyl, and friends who are interested can also refer to it.
Reference:
Patent; REDX PHARMA LIMITED; THOMPSON, William; JACKSON, Peter; LINDSAY, Derek; SCREEN, Thomas; MOLTON, Benjamin; URCH, Christopher; WO2013/136073; (2013); A1;,
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