Application of 22276-95-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22276-95-5, name is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
1,1-dimethylethyl 3-(5-bromo-4-chloro-7H-pyrrolo(2,3-d]pyrimidin-7-yl)-1-azetidine carboxyla teTo a solution of 5-bromo-4-chloro-1 H-pyrrolo[2,3-d]pyrimidine (400 mg, 1 .721 mmol), 1 , 1- dimethylethyl 3-hydroxy-1 -azetidinecarboxylate (894 mg, 5.16 mmol) and triphenylphosphine (903 mg, 3.44 mmol) in Tetrahydrofuran (THF) (10 mL) was added dropwise DEAD (545 muIota, 3.44 mmol). The solution was let stir at room temp. After 1 hr the reaction observed 10% product and the reaction was heated at 60C. After 1 hr observed 80% desired product. Additional 100mg of the 5-bromo-4-chloro-1 H-pyrrolo[2,3- d]pyrimidine was added and heating was continued. The reaction was concentrated then loaded on to a 25g SNAP column with 0 to 35% EtOAc in Hexane gradient over 30minut.es to give 1 , 1-dimethylethyl 3-(5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)- 1-azetidinecarboxylate (624 mg, 94 % yield) as a white solid. LC-MS(ES) m/z = 386.9, 389.1 [M+H]+. 1 H NMR (400 MHz, DMSO-d6) delta 8.69 (s, 1 H), 8.38 (s, 1 H), 5.53 – 5.62 (m, 1 H), 4.33 (d, J = 8.34 Hz, 4H), 1 .43 (s, 9H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22276-95-5, 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine.
Reference:
Patent; GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; GRANT, Seth, Wilson; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul; TANG, Jun; WO2011/119663; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia