Adding a certain compound to certain chemical reactions, such as: 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, blongs to pyrimidines compound. Quality Control of Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate
General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.6 5-[2-(4′-(Trifluoromethoxy)biphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (12) 69% Yield, mp > 250 C 1H NMR delta 11.46 (s, 2H, NH), 8.05 (d, 2H, Jo = 8.3), 7.84-7.90 (m, 4H), 7.49 (d, 2H, Jo = 8.3), 7.32 (s, 1H, OH), 3.93 (s, 2H). Anal. % (C19H13F3N2O6) calculated: C 54.04, H 4.55, N 6.63; found C 53.91, H 4.44, N 6.72.
The synthetic route of 2244-11-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia