Adding a certain compound to certain chemical reactions, such as: 22536-61-4, 2-Chloro-5-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 22536-61-4, blongs to pyrimidines compound. HPLC of Formula: C5H5ClN2
A solution of 2-chloro-5-methylpyrimidine (500 g, 3889 mmol, 1.0 equiv) in DMF (5000 mL) was degassed with N2 for 20 mm and then dppf (108 g, 194 mmol, 0.05 equiv) and Pd2(dba)3 (178 g, 194 mmol, 0.05 equiv) were added to the reaction mixture. Zn(CN)2 (685 g, 5834 mmol, 1.5 equiv) was added, and the reaction mixture was heated at 100 C for 16 h. The reaction was quenched with water (5 L) and stirred for 10 mm. The reaction mixture was filtered through Celite brand filter aid pad. The filtrate was diluted with water (4 L) and extracted with EtOAc (2 x 4 L). The combined organic layers were washed with brine (4 L), dried over Na2SO4, filtered, and concentrated in vacuo to give the initial productwhich was further purified by column chromatography using silica gel (60-120 mesh) and0-10 % EtOAc in hexane to obtain Example 374.01 (330 g, 71 %) as an off white solid.1H NMR (400 MHz, DMSO-d6) oe 8.89 (s, 2H), 2.39 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22536-61-4, its application will become more common.
Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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