Reference of 35265-82-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 35265-82-8, name is 2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
At normal temperature a solution of bromine (1.44 mE, 27.6 mmol) in acetic acid (10 mE) was slowly added dropwise into a solution of 8-g (prepared according to the method ofpatent: W02007/023382A2)(1.984 g, 9.2mmol) and aluminum trichloride (2.46 g, 18.4 mmol) in acetic acid (30 mE). The mixture was heated to 80 C. to react for 6 irs afier the addition was completed. The reaction mixture was cooled, and then partitioned between ethyl acetate (80 mE) and water (80 mE). The organic layer was separated and washed with 5% sodium thiosulfate solution (2×80 mE). The aqueous phase was extracted with ethyl acetate (x2), the combined organic phase was washed sequentially with saturated sodium bicarbonate solution (200 mE) and saturatedbrine (400 mE), dried over anhydrous sodium sulfate, and concentrated under reduced pressure, to yield target compound 8-f(1 .035 g, yield 76%) as a pale yellow solid. EC-MS (ESI): mlz 296.9 (M+H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 35265-82-8, 2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine.
Reference:
Patent; SHANGHAI YINGLI PHARMACEUTICAL CO., LTD; XU, Zusheng; (174 pag.)US2016/214994; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia