Adding a certain compound to certain chemical reactions, such as: 871254-61-4, 2,4-Dichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 871254-61-4, blongs to pyrimidines compound. Recommanded Product: 871254-61-4
The mixture of 9 (8.8 g, 50.0 mmol) and Et3N (15.2 g, 150.0 mmol)in THF (150 mL) was stirred at 0 C for 10 min under argon. To the solution was added 3-nitrobenzylhydrazine dihydrochloride (11.2 g,55.0 mmol) and then warm to r.t. and stirred for 4 h. The solvent wasremoved in vacuo, and the residue was partitioned between CH2Cl2(50 mL) and H2O (100 mL). The layers were separated, and the aqueouslayer was extracted with CH2Cl2 (2 × 50 mL). The combined organiclayers were dried over anhydrous sodium sulfate, filtered, and concentratedto provide the crude product, which was purified by silica gelcolumn chromatography (eluting with 0-10% MeOH in DCM) to provide10a, white solid, yield 62% (9.0 g, 31.1 mmol). 1H NMR(300 MHz, CDCl3) delta 8.93 (s, 1H), 8.25 (m, 1H), 8.18 (m, 1H), 8.07 (s,1H), 7.71 (d, J = 9 Hz, 1H), 7.53 (t, J = 9 Hz, 1H), 5.71 (s, 2H); MS(ESI) m/z: 290.1 [M+H]+.
The synthetic route of 871254-61-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yin, Yuan; Chen, Cheng-Juan; Yu, Ru-Nan; Shu, Lei; Wang, Zhi-Jian; Zhang, Tian-Tai; Zhang, Da-Yong; Bioorganic Chemistry; vol. 98; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia